Article

Genome-scale mapping of DNA damage suppressors identifies GNB1L as essential for ATM and ATR biogenesis

2022-09-24

Abstract excerpt

To maintain genome integrity, cells must avoid DNA damage by ensuring the accurate duplication of the genome and by having efficient repair and signaling systems that counteract the genome-destabilizing potential of DNA lesions. To uncover genes and pathways that suppress DNA damage in human cells, we undertook genome-scale CRISPR/Cas9 screens that monitored the levels of DNA damage in the absence or presence of D...

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Literature Corpus work: dc9536e8-9be9-52b4-b9f2-65165f3da1ac
DOI: 10.1101/2022.09.23.508845

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