IFITM1 inhibits trophoblast invasion and is induced in placentas associated with IFN-mediated pregnancy diseases

Abstract excerpt

Interferon-induced transmembrane proteins (IFITMs) are restriction factors that block many viruses from entering cells. High levels of type I interferon (IFN) are associated with adverse pregnancy outcomes, and IFITMs have been shown to impair the formation of syncytiotrophoblast. Here, we examine whether IFITMs affect another critical step of placental development, extravillous cytotrophoblast (EVCT) invasion....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Pregnancy and preeclampsia studies
• Share to Reproductive System and Pregnancy
• Share to Systemic Lupus Erythematosus Research