Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IFITM proteins inhibit placental syncytiotrophoblast formation and promote fetal demise

12 Jul 2019

Abstract excerpt

Placenta formation and fetal demise A critical step of placental development is the fusion of trophoblast cells into a multi-nucleated syncytiotrophoblast layer. Trophoblast fusion is mediated by syncytins, encoded by endogenous retrovirus–derived envelope glycoproteins. Buchrieser et al. report that interferon-induced transmembrane (IFITM) proteins inhibit syncytin-mediated syncytiotrophoblast formation,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Reproductive System and Pregnancy
Share to interferon and immune responses
Share to Pregnancy and preeclampsia studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31296770
DOI: 10.1126/science.aaw7733

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IFITM proteins inhibit placental syncytiotrophoblast formation and promote fetal demisePMID 31296770Read ↗

IFITMs Inhibit Cell Fusion Mediated by Trophoblast SyncytinsSemantic proximity Read ↗

Interferon-induced transmembrane proteins inhibit cell fusion mediated by trophoblast syncytinsSemantic proximity Read ↗

A three-dimensional culture system recapitulates placental syncytiotrophoblast development and microbial resistanceSemantic proximity Read ↗

IFITM1 inhibits trophoblast invasion and is induced in placentas associated with IFN-mediated pregnancy diseasesSemantic proximity Read ↗

Regulation of human trophoblast syncytialization by histone demethylase LSD1Semantic proximity Read ↗

Zika virus targets human trophoblast stem cells and prevents syncytialization in placental trophoblast organoidsSemantic proximity Read ↗

RNA-Seq identifies genes whose proteins are transformative in the differentiation of cytotrophoblast to syncytiotrophoblast, in human primary villous and BeWo trophoblastsSemantic proximity Read ↗

TFEB controls syncytiotrophoblast differentiationSemantic proximity Read ↗

The proprotein convertase furin is required for trophoblast syncytializationSemantic proximity Read ↗

Trophoblast fusion: Fusogenic proteins, syncytins and ADAMs, and other prerequisites for syncytial fusionSemantic proximity Read ↗

Inhibition of placental trophoblast fusion by guanylate-binding protein 5Semantic proximity Read ↗

Exaptation of Retroviral Syncytin for Development of Syncytialized Placenta, Its Limited Homology to the SARS-CoV-2 Spike Protein and Arguments against Disturbing Narrative in the Context of COVID-19 VaccinationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.