Article

Type I interferon alters invasive extravillous trophoblast function

2024-03-14

Abstract excerpt

<h4>ABSTRACT</h4> Inappropriate type I interferon (IFN) signaling during embryo implantation and placentation is linked to poor pregnancy outcomes. Here, we evaluated the consequence of elevated type I IFN exposure on implantation using a biomimetic model of human implantation in an organ-on-a-chip device. We found that type I IFN reduced extravillous trophoblast (EVT) invasion capacity. Analyzing single-cell tra...

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Literature Corpus work: 2aedc8d6-5e62-51e8-af17-61c639d51570
DOI: 10.1101/2024.03.11.584521

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