Article

The pro-inflammatory cytokines IFN-α and TNF-α inhibit organoid-derived extravillous trophoblast invasion

2025-08-20

Abstract excerpt

Proper placental development requires differentiation and invasion of extravillous trophoblasts (EVTs) into the maternal decidua to ensure adequate remodeling of spiral arteries and support fetal growth. Perturbations in these processes are associated with pregnancy complications such as preeclampsia and fetal growth restriction. The incidence of these pregnancy complications is increased in women with immune-medi...

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Literature Corpus work: 10f2e7b4-c975-58a7-a418-350b85dcf67e
DOI: 10.1101/2025.08.15.670497

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