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Article

Type I interferon exposure of an implantation-on-a-chip device alters invasive extravillous trophoblast function

1 Mar 2025

Abstract excerpt

Inappropriate type I interferon (IFN) signaling during embryo implantation and placentation is linked to poor pregnancy outcomes. Here, we evaluate the consequence of elevated type I IFN exposure on implantation using a human implantation in an organ-on-a-chip device. We reveal that type I IFN reduces extravillous trophoblast (EVT) invasion capacity. Analyzing single-cell transcriptomes, we uncover that IFN...

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Share to Maternal and fetal healthcare
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PMID: 40054459
DOI: 10.1016/j.xcrm.2025.101991

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