Article
Network Connectivity Alterations across the MAPT Mutation Clinical Spectrum.
Annals of neurology - 1 Oct 2023
Zhang Liwen, Flagan Taru M, Häkkinen Suvi, Chu Stephanie A, Brown Jesse A, Lee Alex J, Pasquini Lorenzo, Mandelli Maria Luisa, Gorno-Tempini Maria Luisa, Sturm Virginia E, Yokoyama Jennifer S, Appleby Brian S, Cobigo Yann, Dickerson Bradford C, Domoto-Reilly Kimiko, Geschwind Daniel H, Ghoshal Nupur, Graff-Radford Neill R, Grossman Murray, Hsiung Ging-Yuek Robin, Huey Edward D, Kantarci Kejal, Lario Lago Argentina, Litvan Irene, Mackenzie Ian R, Mendez Mario F, Onyike Chiadi U, Ramos Eliana Marisa, Roberson Erik D, Tartaglia Maria Carmela, Toga Arthur W, Weintraub Sandra, Wszolek Zbigniew K, Forsberg Leah K, Heuer Hilary W, Boeve Bradley F, Boxer Adam L, Rosen Howard J, Miller Bruce L, Seeley William W, Lee Suzee E
Abstract excerpt
OBJECTIVE: Microtubule-associated protein tau (MAPT) mutations cause frontotemporal lobar degeneration, and novel biomarkers are urgently needed for early disease detection. We used task-free functional magnetic resonance imaging (fMRI) mapping, a promising biomarker, to analyze network connectivity in symptomatic and presymptomatic MAPT mutation carriers. METHODS: We compared cross-sectional fMRI data between 17...
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