Article
Altered functional connectivity in asymptomatic MAPT subjects: a comparison to bvFTD.
Neurology - 30 Aug 2011
Whitwell J L, Josephs K A, Avula R, Tosakulwong N, Weigand S D, Senjem M L, Vemuri P, Jones D T, Gunter J L, Baker M, Wszolek Z K, Knopman D S, Rademakers R, Petersen R C, Boeve B F, Jack C R
Abstract excerpt
OBJECTIVE: To determine whether functional connectivity is altered in subjects with mutations in the microtubule associated protein tau (MAPT) gene who were asymptomatic but were destined to develop dementia, and to compare these findings to those in subjects with behavioral variant frontotemporal dementia (bvFTD). METHODS: In this case-control study, we identified 8 asymptomatic subjects with mutations in MAPT...
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