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Network degeneration and dysfunction in presymptomatic C9ORF72 expansion carriers

10 Dec 2016

Abstract excerpt

Hexanucleotide repeat expansions in C9ORF72 are the most common known genetic cause of familial and sporadic frontotemporal dementia and amyotrophic lateral sclerosis. Previous work has shown that patients with behavioral variant frontotemporal dementia due to C9ORF72 show salience and sensorimotor network disruptions comparable to those seen in sporadic behavioral variant frontotemporal dementia, but it remains...

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PMID: 28337409
DOI: 10.1016/j.nicl.2016.12.006

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