Article
Reconfigured metabolism brain network in asymptomatic microtubule-associated protein tau mutation carriers: a graph theoretical analysis.
Alzheimer's research & therapy - 11 Apr 2022
Liu Li, Chu Min, Nie Binbin, Liu Lin, Xie Kexin, Cui Yue, Kong Yu, Chen Zhongyun, Nan Haitian, Chen Kewei, Rosa-Neto Pedro, Wu Liyong
Abstract excerpt
BACKGROUND: Studies exploring topological properties of the metabolic network during the presymptomatic stage of genetic frontotemporal dementia (FTD) are scarce. However, such knowledge is important for understanding brain function and disease pathogenesis. Therefore, we aimed to explore FTD-specific patterns of metabolism topology reconfiguration in microtubule-associated protein tau (MAPT) mutation carriers...
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