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Transcriptional Profile of Human Pancreatic Acinar Ductal Metaplasia

1 Jan 2023

Abstract excerpt

BACKGROUND AND AIMS: Aberrant acinar to ductal metaplasia (ADM), one of the earliest events involved in exocrine pancreatic cancer development, is typically studied using pancreata from genetically engineered mouse models. METHODS: We used primary, human pancreatic acinar cells from organ donors to evaluate the transcriptional and pathway profiles during the course of ADM. RESULTS: Following 6 days of...

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PMID: 37425649
DOI: 10.1016/j.gastha.2023.02.003

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