Article
Single-cell transcriptomes of pancreatic preinvasive lesions and cancer reveal acinar metaplastic cells' heterogeneity.
Nature communications - 9 Sept 2020
Schlesinger Yehuda, Yosefov-Levi Oshri, Kolodkin-Gal Dror, Granit Roy Zvi, Peters Luriano, Kalifa Rachel, Xia Lei, Nasereddin Abdelmajeed, Shiff Idit, Amran Osher, Nevo Yuval, Elgavish Sharona, Atlan Karine, Zamir Gideon, Parnas Oren
Abstract excerpt
Acinar metaplasia is an initial step in a series of events that can lead to pancreatic cancer. Here we perform single-cell RNA-sequencing of mouse pancreas during the progression from preinvasive stages to tumor formation. Using a reporter gene, we identify metaplastic cells that originated from acinar cells and express two transcription factors, Onecut2 and Foxq1. Further analyses of metaplastic acinar cell...
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