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Article

Ring1b-dependent epigenetic remodelling is an essential prerequisite for pancreatic carcinogenesis

6 Apr 2019

Abstract excerpt

BACKGROUND AND AIMS: Besides well-defined genetic alterations, the dedifferentiation of mature acinar cells is an important prerequisite for pancreatic carcinogenesis. Acinar-specific genes controlling cell homeostasis are extensively downregulated during cancer development; however, the underlying mechanisms are poorly understood. Now, we devised a novel in vitro strategy to determine genome-wide dynamics in the...

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PMID: 30954952
DOI: 10.1136/gutjnl-2018-317208

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