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Article

Key transcriptional effectors of the pancreatic acinar phenotype and oncogenic transformation.

PloS one - 1 Jan 2023

Azevedo-Pouly Ana, Hale Michael A, Swift Galvin H, Hoang Chinh Q, Deering Tye G, Xue Jumin, Wilkie Thomas M, Murtaugh L Charles, MacDonald Raymond J

Abstract excerpt

Proper maintenance of mature cellular phenotypes is essential for stable physiology, suppression of disease states, and resistance to oncogenic transformation. We describe the transcriptional regulatory roles of four key DNA-binding transcription factors (Ptf1a, Nr5a2, Foxa2 and Gata4) that sit at the top of a regulatory hierarchy controlling all aspects of a highly differentiated cell-type-the mature pancreatic...

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Share to Acinar Cells
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37796967
DOI: 10.1371/journal.pone.0291512
PMCID: PMC10553828

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