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Article

A transcriptionally distinct subpopulation of healthy acinar cells exhibit features of pancreatic progenitors and PDAC

2021-01-05

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) tumors can originate either from acinar or ductal cells in the adult pancreas. We re-analyze multiple pancreas and PDAC single-cell RNA-seq datasets and find a subset of non-malignant acinar cells, which we refer to as acinar edge (AE) cells, whose transcriptomes highly diverge from a typical acinar cell in each dataset. Genes up-regulated among AE cells are enriched for tra...

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Identifiers and source

Literature Corpus work
eafdc6ad-245a-5509-b7bc-a094d63451e9
DOI
10.1101/2021.01.04.425042
Open publication

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A transcriptionally distinct subpopulation of healthy acinar cells exhibit features of pancreatic progenitors and PDACDOI 10.1101/2021.01.04.425042
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