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Article

Virtual screening and molecular growth guide the design of inhibitors for the influenza virus drug-resistant mutant M2-V27A/S31N.

Journal of biomolecular structure & dynamics - 1 Jul 2024

Deng Changyong, Wang Xiaobo, Wang Tangle, Liu Wei, Yuan Xiaolan, Huang Yan, Cao Shuang

Abstract excerpt

The influenza A virus matrix protein 2 (AM2) protein is a proton-gated, proton-selective ion channel essential for influenza replication that has been identified as an antiviral target. The drug-resistance of the M2-V27A/S31N strain, which has been growing more prevalent in recent years and has the potential to spread globally, prevents current amantadine inhibitors from having the desired impact. In this study,...

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Identifiers

PMID: 37424098
DOI: 10.1080/07391102.2023.2233026

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