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Article

Discovery of M2 channel blockers targeting the drug-resistant double mutants M2-S31N/L26I and M2-S31N/V27A from the influenza A viruses.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences - 1 Jan 2020

Musharrafieh Rami, Ma Chunlong, Wang Jun

Abstract excerpt

Influenza virus infections are a persistent threat to human health due to seasonal outbreaks and sporadic pandemics. Amantadine and rimantadine are FDA-approved influenza antiviral drugs and work by inhibiting the viral M2 proton channel. However, the therapeutic potential for the antiviral amantadine/rimantadine was curtailed by the emergence of drug-resistant mutations in its target protein M2. In this study,...

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Identifiers

PMID: 31669761
DOI: 10.1016/j.ejps.2019.105124
PMCID: PMC6951800

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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