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Virtual Screening Identifies Chebulagic Acid as an Inhibitor of the M2(S31N) Viral Ion Channel and Influenza A Virus.

Molecules (Basel, Switzerland) - 24 Jun 2020

Duncan Maggie C, Onguéné Pascal Amoa, Kihara Ibuki, Nebangwa Derrick N, Naidu Maya E, Williams David E, Balgi Aruna D, Andrae-Marobela Kerstin, Roberge Michel, Andersen Raymond J, Niikura Masahiro, Ntie-Kang Fidele, Tietjen Ian

Abstract excerpt

The increasing prevalence of drug-resistant influenza viruses emphasizes the need for new antiviral countermeasures. The M2 protein of influenza A is a proton-gated, proton-selective ion channel, which is essential for influenza replication and an established antiviral target. However, all currently circulating influenza A virus strains are now resistant to licensed M2-targeting adamantane drugs, primarily due to...

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PMID: 32599753
DOI: 10.3390/molecules25122903
PMCID: PMC7356874

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Virtual Screening Identifies Chebulagic Acid as an Inhibitor of the M2(S31N) Viral Ion Channel and Influenza A Virus.PMID 32599753Read ↗

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