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Article

Crystal structure of the drug-resistant S31N influenza M2 proton channel.

Protein science : a publication of the Protein Society - 1 Aug 2016

Thomaston Jessica L, DeGrado William F

Abstract excerpt

The M2 protein is a small proton channel found in the influenza A virus that is necessary for viral replication. The M2 channel is the target of a class of drugs called the adamantanes, which block the channel pore and prevent the virus from replicating. In recent decades mutations have arisen in M2 that prevent the adamantanes from binding to the channel pore, with the most prevalent of these mutations being...

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Identifiers

PMID: 27082171
DOI: 10.1002/pro.2937
PMCID: PMC4972211

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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