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Article

Discovery of novel dual inhibitors of the wild-type and the most prevalent drug-resistant mutant, S31N, of the M2 proton channel from influenza A virus.

Journal of medicinal chemistry - 11 Apr 2013

Wang Jizhou, Ma Chunlong, Wang Jun, Jo Hyunil, Canturk Belgin, Fiorin Giacomo, Pinto Lawrence H, Lamb Robert A, Klein Michael L, DeGrado William F

Abstract excerpt

Anti-influenza drugs, amantadine and rimantadine, targeting the M2 channel from influenza A virus are no longer effective because of widespread drug resistance. S31N is the predominant and amantadine-resistant M2 mutant, present in almost all of the circulating influenza A strains as well as in the pandemic 2009 H1N1 and the highly pathogenic H5N1 flu strains. Thus, there is an urgent need to develop...

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Identifiers

PMID: 23437766
DOI: 10.1021/jm301538e
PMCID: PMC4036227

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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