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Article

The RNA-Binding Domain NS1 of Influenza as an Antiviral Target: From Evolutionary Conservation Mapping to Experimental Validation.

Viruses - 25 Feb 2026

Santos Luis André, Trigueiro-Louro João, Rebelo-de-Andrade Helena

Abstract excerpt

Non-structural protein 1 (NS1) of influenza A virus is a multifunctional virulence factor and represents a promising anti-influenza target, considering its conserved and druggable structure. As antiviral target, NS1-RNA-binding domain (RBD) remains unexplored, despite its critical role in replication. In this study, we applied a "Map-and-Mutate" strategy to identify and functionally validate highly conserved and...

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Share to Antiviral Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41902187
DOI: 10.3390/v18030279
PMCID: PMC13029851

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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