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Antiviral mechanisms and preclinical evaluation of amantadine analogs that continue to inhibit influenza A viruses with M2S31N-based drug resistance.

Antiviral research - 1 Apr 2025

Tietjen Ian, Kwan Daniel C, Petrich Annett, Zell Roland, Antoniadou Ivi Theodosia, Gavriilidou Agni, Tzitzoglaki Christina, Rallis Michail, Fedida David, Sureda Francesc X, Mestdagh Cato, Naesens Lieve, Chiantia Salvatore, Johnson F Brent, Kolocouris Antonios

Abstract excerpt

To better manage seasonal and pandemic influenza infections, new drugs are needed with enhanced activity against amantadine- and rimantadine-resistant influenza A virus (IAV) strains containing the S31N variant of the viral M2 ion channel (M2S31N). Here we tested 36 amantadine analogs against a panel of viruses containing either M2S31N or the parental, M2 S31 wild-type variant (M2WT). We found that several...

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PMID: 39947434
DOI: 10.1016/j.antiviral.2025.106104

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