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Article

Structural comparison of the wild-type and drug-resistant mutants of the influenza A M2 proton channel by molecular dynamics simulations.

The journal of physical chemistry. B - 23 May 2013

Gu Ruo-Xu, Liu Limin Angela, Wang Yong-Hua, Xu Qin, Wei Dong-Qing

Abstract excerpt

The influenza A M2 channel in the viral envelope is a pH-regulated proton channel that is crucial for viral infection and replication. Amantadine and rimantadine are two M2 inhibitors that have been widely used as anti-influenza drugs. However, due to naturally occurring drug-resistant mutations, their inhibition ability has gradually decreased. These drug-resistant mutations are found at various positions on the...

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Identifiers

PMID: 23594107
DOI: 10.1021/jp312396q

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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