Article
Flipping in the pore: discovery of dual inhibitors that bind in different orientations to the wild-type versus the amantadine-resistant S31N mutant of the influenza A virus M2 proton channel.
Journal of the American Chemical Society - 31 Dec 2014
Wu Yibing, Canturk Belgin, Jo Hyunil, Ma Chunlong, Gianti Eleonora, Klein Michael L, Pinto Lawrence H, Lamb Robert A, Fiorin Giacomo, Wang Jun, DeGrado William F
Abstract excerpt
Influenza virus infections lead to numerous deaths and millions of hospitalizations each year. One challenge facing anti-influenza drug development is the heterogeneity of the circulating influenza viruses, which comprise several strains with variable susceptibility to antiviral drugs. For exampl...
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