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Article

Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus.

Proceedings of the National Academy of Sciences of the United States of America - 22 Jan 2013

Wang Jun, Wu Yibing, Ma Chunlong, Fiorin Giacomo, Wang Jizhou, Pinto Lawrence H, Lamb Robert A, Klein Michael L, Degrado William F

Abstract excerpt

The influenza A virus M2 proton channel (A/M2) is the target of the antiviral drugs amantadine and rimantadine, whose use has been discontinued due to widespread drug resistance. Among the handful of drug-resistant mutants, S31N is found in more than 95% of the currently circulating viruses and shows greatly decreased inhibition by amantadine. The discovery of inhibitors of S31N has been hampered by the limited...

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Identifiers

PMID: 23302696
DOI: 10.1073/pnas.1216526110
PMCID: PMC3557100

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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