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Article

Extracellular chloride modulates the desensitization kinetics of acid-sensing ion channel 1a (ASIC1a).

The Journal of biological chemistry - 4 Jun 2010

Kusama Nobuyoshi, Harding Anne Marie S, Benson Christopher J

Abstract excerpt

Acid-sensing ion channels (ASICs) are sodium channels gated by extracellular protons. The recent crystallization of ASIC1a identified potential binding sites for Cl(-) in the extracellular domain that are highly conserved between ASIC isoforms. However, the significance of Cl(-) binding is unknown. We investigated the effect of Cl(-) substitution on heterologously expressed ASIC1a current and H(+)-gated currents...

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Identifiers

PMID: 20385551
DOI: 10.1074/jbc.M109.091561
PMCID: PMC2878506

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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