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Article

Germline predisposition to clonal hematopoiesis.

Leukemia research - 1 Sept 2023

Liu Jie, Osman Afaf E G, Bolton Kelly, Godley Lucy A

Abstract excerpt

We now recognize that with aging, hematopoietic stem and progenitor cells (HSPCs) acquire mutations that confer a fitness advantage and clonally expand in a process now termed clonal hematopoiesis (CH). Because CH predisposes to a variety of health problems, including cancers, cardiovascular diseases, and inflammatory conditions, there is intense interest in the inherited alleles associated with the development...

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Identifiers

PMID: 37421681
DOI: 10.1016/j.leukres.2023.107344

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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