Clinical and Therapeutic Implications of Clonal Hematopoiesis.

Abstract excerpt

Clonal hematopoiesis (CH) is an age-related process whereby hematopoietic stem and progenitor cells (HSPCs) acquire mutations that lead to a proliferative advantage and clonal expansion. The most commonly mutated genes are epigenetic regulators, DNA damage response genes, and splicing factors, which are essential to maintain functional HSPCs and are frequently involved in the development of hematologic...

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• Mutation
• Clonal Hematopoiesis
• Epigenesis, Genetic
• Hematologic Neoplasms
• Hematopoietic Stem Cells