Article

Matrix stress-relaxation and stiffness modulate oligodendrocyte differentiation

2025-10-10

Abstract excerpt

Impaired remyelination capacity, observed not only in demyelinating diseases of the central nervous system (CNS) but also in the aging brain, features a critical challenge in neural repair. Dysfunctional oligodendrocytes (OLs) are not able to efficiently restore myelin sheaths leading to increased axonal susceptibility to degeneration. Inhibitory cues to OL myelination have been described but strategies promoting...

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Literature Corpus work: 68d3628a-4134-56eb-96af-8ece8fb8a549
DOI: 10.1101/2025.10.09.680975

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