Article

Altered Extracellular Matrix Structure and Elevated Stiffness in a Brain Organoid Model for Disease

2024-01-09

Abstract excerpt

The viscoelasticity of tissues impacts their shape, as well as the growth and differentiation of their cells. Nevertheless, little is known about changes in viscoelastic properties during brain malformations. Lissencephaly is a severe malformation of cortical development caused by LIS1 mutations, which results in a lack of cortical convolutions. Here, we show that human-derived brain organoids with LIS1 mutation...

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Literature Corpus work: 64545a23-9469-5e1c-822b-2cbaadb7e1fe
DOI: 10.1101/2024.01.09.574777

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