Article

Influence of substrate stiffness on barrier function in an iPSC-derived in vitro blood-brain barrier model

2021-03-31

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Introduction</h4> Vascular endothelial cells respond to a variety of biophysical cues such as shear stress and substrate stiffness. In peripheral vasculature, extracellular matrix (ECM) stiffening alters barrier function, leading to increased vascular permeability in atherosclerosis and pulmonary edema. The effect of ECM stiffness on blood-brain barrier (BBB) endothelial cells, however, has...

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Literature Corpus work: 98041058-28be-57a6-93fb-8e0c28bccf88
DOI: 10.1101/2021.03.31.437924

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