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Article

Substrate stiffness and shear stress collectively regulate the inflammatory phenotype in cultured human brain microvascular endothelial cells.

Fluids and barriers of the CNS - 15 Jul 2025

Yates Alexis K, Murray Heather, Kjar Andrew, Chavarria Daniel, Masters Haley, Kim Hyosung, Ligocki Alexander P, Jefferson Angela L, Lippmann Ethan S

Abstract excerpt

Brain endothelial cells experience mechanical forces in the form of blood flow-mediated shear stress and underlying matrix stiffness, but intersectional contributions of these factors towards blood-brain barrier (BBB) impairment and neurovascular dysfunction have not been extensively studied. Here, we developed in vitro models to examine the sensitivity of primary human brain microvascular endothelial cells...

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Identifiers

PMID: 40665329
DOI: 10.1186/s12987-025-00683-4
PMCID: PMC12261575

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