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Substrate stiffness and shear stress collectively regulate the inflammatory phenotype in cultured human brain microvascular endothelial cells

2025-04-02

Abstract excerpt

Brain endothelial cells experience mechanical forces in the form of blood flow-mediated shear stress and underlying matrix stiffness, but intersectional contributions of these factors towards blood-brain barrier (BBB) impairment and neurovascular dysfunction have not been extensively studied. Here, we developed in vitro models to examine the sensitivity of primary human brain microvascular endothelial cells (BMEC...

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Literature Corpus work
3dced836-081a-5e76-98e9-ba7f9697914d
DOI
10.1101/2025.03.31.646228
Open publication

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Substrate stiffness and shear stress collectively regulate the inflammatory phenotype in cultured human brain microvascular endothelial cellsDOI 10.1101/2025.03.31.646228
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