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Article

Identification of Driver Epistatic Gene Pairs Combining Germline and Somatic Mutations in Cancer.

International journal of molecular sciences - 26 May 2023

Rocha Jairo, Sastre Jaume, Amengual-Cladera Emilia, Hernandez-Rodriguez Jessica, Asensio-Landa Victor, Heine-Suñer Damià, Capriotti Emidio

Abstract excerpt

Cancer arises from the complex interplay of various factors. Traditionally, the identification of driver genes focuses primarily on the analysis of somatic mutations. We describe a new method for the detection of driver gene pairs based on an epistasis analysis that considers both germline and somatic variations. Specifically, the identification of significantly mutated gene pairs entails the calculation of a...

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Source

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Identifiers

PMID: 37298272
DOI: 10.3390/ijms24119323
PMCID: PMC10253732

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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