Pervasive conditional selection of driver mutations and modular epistasis networks in cancer.

Abstract excerpt

Cancer driver mutations often display mutual exclusion or co-occurrence, underscoring the key role of epistasis in carcinogenesis. However, estimating the magnitude of epistasis and quantifying its effect on tumor evolution remains a challenge. We develop a method (Coselens) to quantify conditional selection on the excess of nonsynonymous substitutions in cancer genes. Coselens infers the number of drivers per...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Computational Biology
• Share to Epistasis, Genetic
• Share to Gene Regulatory Networks