Article
Epistatic interactions and drug response.
The Journal of pathology - 1 Jan 2014
Weigelt Britta, Reis-Filho Jorge S
Abstract excerpt
The advent of massively parallel sequencing has allowed for an unprecedented genetic characterization of cancers, which has revealed not only the complexity of cancer genomes, but also the fact that tumours from the same anatomical site or even of the same histological and/or molecular subtype display distinct constellations of somatic genetic aberrations. Epistatic interactions (ie the interplay between genetic...
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