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Article

Cancer type-dependent genetic interactions between cancer driver alterations indicate plasticity of epistasis across cell types.

Molecular systems biology - 30 Jul 2015

Park Solip, Lehner Ben

Abstract excerpt

Cancers, like many diseases, are normally caused by combinations of genetic alterations rather than by changes affecting single genes. It is well established that the genetic alterations that drive cancer often interact epistatically, having greater or weaker consequences in combination than expected from their individual effects. In a stringent statistical analysis of data from > 3,000 tumors, we find that the...

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Identifiers

PMID: 26227665
DOI: 10.15252/msb.20156102
PMCID: PMC4547852

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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