Article
Role of polymorphisms of toll-like receptor (TLR) 4, TLR9, toll-interleukin 1 receptor domain containing adaptor protein (TIRAP) and FCGR2A genes in malaria susceptibility and severity in Burundian children.
Malaria journal - 12 Jun 2012
Esposito Susanna, Molteni Claudio Giuseppe, Zampiero Alberto, Baggi Elena, Lavizzari Anna, Semino Margherita, Daleno Cristina, Groppo Michela, Scala Alessia, Terranova Leonardo, Miozzo Monica, Pelucchi Claudio, Principi Nicola
Abstract excerpt
BACKGROUND: Malaria caused by Plasmodium falciparum is one of the leading causes of human morbidity and mortality from infectious diseases, predominantly in tropical and sub-tropical countries. As genetic variations in the toll-like receptors (TLRs)-signalling pathway have been associated with either susceptibility or resistance to several infectious and inflammatory diseases, the supposition is that single...
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