Molecular and structural mechanisms of ZZ domain-mediated cargo selection by Nbr1.

Abstract excerpt

In selective autophagy, cargo selectivity is determined by autophagy receptors. However, it remains scarcely understood how autophagy receptors recognize specific protein cargos. In the fission yeast Schizosaccharomyces pombe, a selective autophagy pathway termed Nbr1-mediated vacuolar targeting (NVT) employs Nbr1, an autophagy receptor conserved across eukaryotes including humans, to target cytosolic hydrolases...

Topics

• Binding Sites
• Cryoelectron Microscopy
• Intracellular Signaling Peptides and Proteins
• Mutation
• Protein Domains
• Schizosaccharomyces
• Schizosaccharomyces pombe Proteins