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Article

Transcription Factor Deformed Wings Is an Atg8a-Interacting Protein That Regulates Autophagy.

Cells - 17 Nov 2024

Kołodziej Marta, Tsapras Panagiotis, Cameron Alexander D, Nezis Ioannis P

Abstract excerpt

LC3 (microtubule-associated protein 1 light chain 3, called Atg8 in yeast and Drosophila) is one of the most well-studied autophagy-related proteins. LC3 controls the selectivity of autophagic degradation by interacting with LIR (LC3-interacting region) motifs also known as AIM (Atg8-interacting motifs) on selective autophagy receptors that carry cargo for degradation. Although the function of Atg8 family...

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PMID: 39594645
DOI: 10.3390/cells13221897
PMCID: PMC11592666

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