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Degradation of the antiviral component ARGONAUTE1 by the autophagy pathway

10 Sept 2012

Abstract excerpt

Posttranscriptional gene silencing (PTGS) mediated by siRNAs is an evolutionarily conserved antiviral defense mechanism in higher plants and invertebrates. In this mechanism, viral-derived siRNAs are incorporated into the RNA-induced silencing complex (RISC) to guide degradation of the corresponding viral RNAs. In Arabidopsis, a key component of RISC is ARGONAUTE1 (AGO1), which not only binds to siRNAs but also...

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PMID: 23019378
DOI: 10.1073/pnas.1209487109

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Research trail→

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Degradation of the antiviral component ARGONAUTE1 by the autophagy pathwayPMID 23019378Read ↗

The viral F-box protein P0 induces an ER-derived autophagy degradation pathway for the clearance of membrane-bound AGO1Semantic proximity Read ↗

The miRNA pathway limits AGO1 availability during siRNA-mediated PTGS defense against exogenous RNA.Semantic proximity Read ↗

VCP Machinery Mediates Autophagic Degradation of Empty ArgonauteSemantic proximity Read ↗

A small peptide inhibits siRNA amplification in plants by mediating autophagic degradation of SGS3/RDR6 bodies.Semantic proximity Read ↗

Plant ARGONAUTES.Semantic proximity Read ↗

The action of ARGONAUTE1 in the miRNA pathway and its regulation by the miRNA pathway are crucial for plant development.Semantic proximity Read ↗

mRNA Decay of Most Arabidopsis miRNA Targets Requires Slicer Activity of AGO1.Semantic proximity Read ↗

The developmental outcomes of P0-mediated ARGONAUTE destabilization in tomato.Semantic proximity Read ↗

Viral Protein Inhibits RISC Activity by Argonaute Binding through Conserved WG/GW MotifsSemantic proximity Read ↗

The N-coil and the globular N-terminal domain of plant ARGONAUTE1 are interaction hubs for regulatory factors.Semantic proximity Read ↗

Functional analysis of three Arabidopsis ARGONAUTES using slicer-defective mutants.Semantic proximity Read ↗

AGO1 homeostasis entails coexpression of MIR168 and AGO1 and preferential stabilization of miR168 by AGO1.Semantic proximity Read ↗

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