Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

VCP Machinery Mediates Autophagic Degradation of Empty Argonaute

1 Jul 2019

Abstract excerpt

The Argonaute subfamily of proteins (AGO) loads microRNAs (miRNAs) to form the effector complex that mediates target gene silencing. Empty AGO, but not miRNA-loaded AGO, is selectively degraded across species. We have reported that the degradation of empty AGO is part of a quality control pathway that eliminates dysfunctional AGO. However, how empty AGO is degraded remains unclear. Here we show that the empty...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to RNA Interference and Gene Delivery
Share to Studies on Chitinases and Chitosanases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31365860
DOI: 10.1016/j.celrep.2019.07.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

VCP Machinery Mediates Autophagic Degradation of Empty ArgonautePMID 31365860Read ↗

Degradation of the antiviral component ARGONAUTE1 by the autophagy pathwaySemantic proximity Read ↗

The viral F-box protein P0 induces an ER-derived autophagy degradation pathway for the clearance of membrane-bound AGO1Semantic proximity Read ↗

The Ubiquitin-Proteasome Pathway Mediates Selective Degradation of Unloaded Argonautes in <i>C. elegans</i>Semantic proximity Read ↗

Plant ARGONAUTES.Semantic proximity Read ↗

Selective autophagy degrades DICER and AGO2 and regulates miRNA activitySemantic proximity Read ↗

Systematic identification of C. elegans miRISC proteins, miRNAs, and mRNA targets by their interactions with GW182 proteins AIN-1 and AIN-2.Semantic proximity Read ↗

OMVs-Delivered Vibrio splendidus sRNA063 OrchestratesPDZRN3-Mediated K48-Linked Polyubiquitination of ATG2 toSuppress Autophagy in EchinodermsSemantic proximity Read ↗

The N-coil and the globular N-terminal domain of plant ARGONAUTE1 are interaction hubs for regulatory factors.Semantic proximity Read ↗

A role for the P-body component GW182 in microRNA function.Semantic proximity Read ↗

ARGONAUTE10 promotes the degradation of miR165/6 through the SDN1 and SDN2 exonucleases in Arabidopsis.Semantic proximity Read ↗

Argonaute proteins regulate microRNA stability: Increased microRNA abundance by Argonaute proteins is due to microRNA stabilization.Semantic proximity Read ↗

Autophagy modulates miRNA-mediated gene silencing and selectively degrades AIN-1/GW182 in C. elegans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.