The influence of growth and sex hormones on risk of alzheimer's disease: a mendelian randomization study.

doi:10.1007/s10654-023-01015-2

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Article

The influence of growth and sex hormones on risk of alzheimer's disease: a mendelian randomization study.

European journal of epidemiology - 1 Jul 2023

Yeung Chris Ho Ching, Au Yeung Shiu Lun, Kwok Man Ki, Zhao Jie V, Schooling C Mary

Abstract excerpt

Alzheimer's disease is more prevalent in women, possibly due to sex or growth hormones but existing evidence is inconclusive. We investigated whether genetically predicted sex and growth hormones are associated with risk of Alzheimer's disease. Genetic variants strongly and independently predicting insulin-like growth factor 1 (IGF-1), testosterone and sex hormone-binding globulin (SHBG) were obtained from large,...

Topics

Humans
Female
Alzheimer Disease
Insulin-Like Growth Factor I
Mendelian Randomization Analysis
Gonadal Steroid Hormones
Testosterone
Genome-Wide Association Study
Polymorphism, Single Nucleotide

Source

Open in PubMed

Identifiers

PMID: 37253999
DOI: 10.1007/s10654-023-01015-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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