Article
Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study.
PLoS medicine - 1 Jun 2015
Østergaard Søren D, Mukherjee Shubhabrata, Sharp Stephen J, Proitsi Petroula, Lotta Luca A, Day Felix, Perry John R B, Boehme Kevin L, Walter Stefan, Kauwe John S, Gibbons Laura E, Larson Eric B, Powell John F, Langenberg Claudia, Crane Paul K, Wareham Nicholas J, Scott Robert A
Abstract excerpt
BACKGROUND: Potentially modifiable risk factors including obesity, diabetes, hypertension, and smoking are associated with Alzheimer disease (AD) and represent promising targets for intervention. However, the causality of these associations is unclear. We sought to assess the causal nature of these associations using Mendelian randomization (MR). METHODS AND FINDINGS: We used SNPs associated with each risk factor...
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