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Article

Among men, androgens are associated with a decrease in Alzheimer's disease risk.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Sept 2023

Kusters Cynthia D J, Paul Kimberly C, Romero Tahmineh, Sinsheimer Janet S, Ritz Beate R

Abstract excerpt

INTRODUCTION: Increased levels of sex hormones have been hypothesized to decrease Alzheimer's disease (AD) risk. We assessed the association between sex steroid hormones with AD using a Mendelian randomization (MR) approach. METHODS: An inverse-variance weighting (IVW) MR analysis was performed using effect estimates from external genome-wide association study (GWAS) summary statistics. We included independent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36938850
DOI: 10.1002/alz.13013
PMCID: PMC10509321

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