Article
Genetically predicted body mass index and Alzheimer's disease-related phenotypes in three large samples: Mendelian randomization analyses.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Dec 2015
Mukherjee Shubhabrata, Walter Stefan, Kauwe John S K, Saykin Andrew J, Bennett David A, Larson Eric B, Crane Paul K, Glymour M Maria
Abstract excerpt
Observational research shows that higher body mass index (BMI) increases Alzheimer's disease (AD) risk, but it is unclear whether this association is causal. We applied genetic variants that predict BMI in Mendelian randomization analyses, an approach that is not biased by reverse causation or confounding, to evaluate whether higher BMI increases AD risk. We evaluated individual-level data from the AD Genetics...
Topics
- Aged
- Aged, 80 and over
- Alzheimer Disease
- Body Mass Index
- Female
- Genotype
- Humans
- Linear Models
- Male
- Mendelian Randomization Analysis
- Obesity
- Phenotype
- Polymorphism, Single Nucleotide