Article
Potential Causal Association Between Follicle-Stimulating Hormone and Alzheimer's Disease: Genetic Loci Study and Mendelian Randomization Study.
Annals of human genetics - 1 Jan 2026
Ding Chenchen, Xu Xiaohong, Xu Bangliang, Wu Jiali
Abstract excerpt
BACKGROUND: Alzheimer's disease (AD) predominantly affects older women, with research suggesting elevated follicle-stimulating hormone (FSH) levels in postmenopausal women correlate with AD risk and cognitive decline. Understanding the causal relationship between FSH and AD is essential. MATERIALS AND METHODS: We selected single-nucleotide polymorphisms (SNPs) linked to FSH as instrumental variables (IVs) for...
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