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Article

A mutation in switch I alters the load-dependent kinetics of myosin Va.

Nature communications - 30 May 2023

Marang Christopher, Scott Brent, Chambers James, Gunther Laura K, Yengo Christopher M, Debold Edward P

Abstract excerpt

Myosin Va is the molecular motor that drives intracellular vesicular transport, powered by the transduction of chemical energy from ATP into mechanical work. The coupling of the powerstroke and phosphate (Pi) release is key to understanding the transduction process, and crucial details of this process remain unclear. Therefore, we determined the effect of elevated Pi on the force-generating capacity of a...

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Identifiers

PMID: 37253724
DOI: 10.1038/s41467-023-38535-0
PMCID: PMC10229639

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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