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Article

Mechanics of blunting of actin-myosin interaction dynamics by the actinopathy-causing mutation E334Q in cytoskeletal γ-actin.

The Journal of physiology - 1 Jan 2026

Pertici Irene, Buonfiglio Valentina, Greve Johannes N, Battirossi Elena, Fanelli Duccio, Manstein Dietmar J, Bianco Pasquale

Abstract excerpt

Cellular processes such as cytokinesis, apoptosis and migration rely heavily on the myosin-based contractility of the γ-actin network in the submembrane cortex. Direct measurements of γ-actin-myosin interactions through morphological and depletion investigations remain elusive. Here, we use a synthetic nanomachine, consisting of an array of myosin motors carried on a nanopositioner and brought to interact with an...

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PMID: 41243338
DOI: 10.1113/JP289622
PMCID: PMC12783979

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