Article

Controlling load-dependent contractility of the heart at the single molecule level

2018-01-31

Abstract excerpt

Concepts in molecular tension sensing in biology are growing and have their origins in studies of muscle contraction. In the heart muscle, a key parameter of contractility is the detachment rate from actin of myosin, which determines the time that myosin is bound to actin in a force-producing state and, importantly, depends on the load (force) against which myosin works. Here, we measure the detachment rate of sin...

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Literature Corpus work: 903dbac1-70fc-5178-b271-add2b22ee37d
DOI: 10.1101/258020

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